特任教授(shou)，博士生導師(shi)，入(ru)選國家海外(wai)高層次人才引進計劃，免(mian)(mian)疫應答與(yu)免(mian)(mian)疫治(zhi)療重(zhong)點實(shi)驗室(shi)、微尺度物質科(ke)學國家研究中心、中國科(ke)學院天然免(mian)(mian)疫與(yu)慢性疾病重(zhong)點實(shi)驗室(shi)、安(an)徽省(sheng)新發突發傳染病重(zhong)點實(shi)驗室(shi)PI。多年來一直致力于(yu)人體共(gong)生菌群(qun)與健康(kang)和疾病的相關研究，學術成果以第一或(huo)通(tong)訊作者身(shen)份發表(biao)于(yu)Nature、Nature Communications、Nature Reviews Gastroenterology & Hepatology、Journal of Hepatology、Gut等高影響因子期刊，并被Nature、Science、Cell、Nature Reviews Drug Discovery、Nature Reviews Gastroenterology & Hepatology、Cell Host & Microbe，Hepatology等國(guo)際著名刊物(wu)點評報道，獲得Faculty of 1000收錄并被兩位獨立(li)推薦人分別(bie)給(gei)予最高等(deng)級(ji)評價。迄今(jin)共發表SCI論文(wen)35篇(pian)（其(qi)中17篇(pian)IF>10），申請發明專(zhuan)利1項，相關成果被(bei)引用2700余次(ci)，單篇最高被引485次(ci)。受(shou)邀(yao)參加多場國(guo)際國(guo)內學術交流(liu)會(hui)議并做口頭報告，擔任iMeta，mLife等(deng)期刊編輯和Nature Communications，Science Advances等(deng)期刊審(shen)稿(gao)人，受邀擔任中國(guo)生物工程學會(hui)噬菌體專(zhuan)業技術委員會(hui)首任委員。
教育及工(gong)作經(jing)歷：
2022年-至(zhi)今 188bet足球生命科學與醫學部，教授，博士生導(dao)師
2017-2022年 美國加利福(fu)尼亞(ya)大學(xue)圣地亞(ya)哥分校醫學(xue)院，博士后研究學(xue)者
2011-2016年 美(mei)國德州農工大(da)學生物(wu)化(hua)學與生物(wu)物(wu)理系，獲生物(wu)化(hua)學博士學位
2007-2011年(nian) 188bet足球生命(ming)科學(xue)學(xue)院，獲生物科學(xue)學(xue)士學(xue)位(wei)
主要研究(jiu)興趣：
人體(ti)腸道內存在著超過1000種(zhong)，與人(ren)體(ti)自身細(xi)胞數量相當的微生物種(zhong)群。這一人(ren)體(ti)“最大的(de)器官(guan)”，攜(xie)帶著百倍于(yu)人體自身基因數量的“第二套基因組”，在維持機(ji)體(ti)(ti)健康方面發揮著不可或缺的(de)(de)(de)作用。大量研究表明，腸道菌群紊(wen)亂(luan)與包括消化系統疾(ji)病、神經(jing)系統疾(ji)病等在內的(de)(de)(de)多種(zhong)人體(ti)(ti)疾(ji)病，具(ju)有顯(xian)著相(xiang)關性。深(shen)入探究其具(ju)體(ti)(ti)的(de)(de)(de)分子致病機(ji)理，并據此開(kai)發相(xiang)應的(de)(de)(de)新(xin)型診療策略和方法，具(ju)有重要的(de)(de)(de)科學意義和臨(lin)床價值。
噬菌(jun)體是(shi)細(xi)(xi)菌(jun)的(de)天然宿(su)敵。它(ta)們(men)只侵染細(xi)(xi)菌(jun)而不感染動(dong)物細(xi)(xi)胞，具(ju)有(you)高度的(de)宿(su)主特異(yi)性(xing)。在抗生素耐藥問題日益嚴峻的(de)今天，噬菌(jun)體療(liao)法正受(shou)到越(yue)(yue)來越(yue)(yue)多的(de)關(guan)注，成為當今微生物學研究領域的(de)前沿熱點(dian)方(fang)向之一(yi)。利用(yong)噬菌(jun)體還(huan)可(ke)以對腸(chang)道(dao)細(xi)(xi)菌(jun)進行“精準打擊(ji)，定(ding)點(dian)清除”，為精準編(bian)輯腸(chang)道(dao)菌(jun)群(qun)提供(gong)了一(yi)條可(ke)行的(de)思路(lu)，從而為菌(jun)群(qun)相(xiang)關(guan)的(de)人體疾病新型生物療(liao)法的(de)開發，奠定(ding)堅實的(de)基礎。
課題(ti)組圍繞“腸道微(wei)生物與人(ren)體健康”這一(yi)主(zhu)題(ti)，主(zhu)要(yao)開(kai)展以下(xia)方面(mian)的研究：
1. 腸(chang)道微生物對代(dai)謝性(xing)及免(mian)疫性(xing)疾(ji)病，尤其是慢性(xing)肝(gan)病的影響及其具體分(fen)子機(ji)制；
2. 微(wei)生物相關生物療(liao)法，尤其是噬菌體(ti)療(liao)法的(de)開發及應用；
3. 腸道微生物(wu)研(yan)究相關新(xin)技術與(yu)新(xin)方法的研(yan)制開發。
代表(biao)性(xing)論著（#共同第一(yi)作者，*通訊(xun)作者(zhe)）：
1. Duan Y#, Llorente C#, Lang S, Brandl K, Chu H, Jiang L, et al. (2019). Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature. 575(7783): 505-511. doi: 10.1038/s41586-019-1742-x.
Recommended by Faculty of 1000 (Two recommendations from two independent experts). https:/f1000.com/prime/736896846; Featured article and highlighted in Nature, Science, Cell, Nature Reviews Drug Discovery, Nature Reviews Gastroenterology & Hepatology, Hepatology and Environmental Microbiology:
Microbial clues to a liver disease. Nature. doi: 10.1038/d41586-019-03417-3
Toxic gut bacteria make alcohol-triggered liver disease more deadly. Science. doi: 10.1126/science.aba2064
Bacteriophage prevents alcoholic liver disease. Cell. doi: 10.1016/j.cell.2019.12.034
Phages fight alcoholic hepatitis. Nature Reviews Drug Discovery. doi: 10.1038/d41573-019-00198-2
Manipulating the gut microbiota to combat alcoholic hepatitis. Nature Reviews Gastroenterology & Hepatology. doi: 10.1038/s41575-019-0246-3
Phage therapy for alcoholic hepatitis. Hepatology. doi: 10.1002/hep.31623
Hope for alcoholics from phage therapy? Environmental Microbiology. doi: 10.1111/1462-2920.14898
2. Xie S#, Li J#, Lyu F#, Xiong Q#, et al., Duan Y*, Jiang Y*, Zhou H*, Chen P*. (2023). Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis. Gut. 14(3):490. doi: 10.1136/gutjnl-2023-329996.
3. Chen X#, Mendes BG#, Alves BS, Duan Y*. (2023). Phage therapy in gut microbiome. Progress in Molecular Biology and Translational Science. doi: 10.1016/bs.pmbts.2023.04.005.
4. Duan Y, Young R, Schnabl B. (2022). Bacteriophages and their potential for treatment of gastrointestinal diseases. Nature Reviews Gastroenterology & Hepatology. 19(2):135-144. doi: 10.1038/s41575-021-00536-z.
5. Mendes BG#, Duan Y#, Schnabl B. (2022). Immune response of an oral Enterococcus faecalis phage cocktail in a mouse model of ethanol-induced liver disease. Viruses. 14(3):490. doi: 10.3390/v14030490.
6. Duan Y#, Chu H#, Brandl K, Jiang L, Zeng S, Mendes BG, et al. (2021). CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. Nature Communications. 12(1):7172. doi: 10.1038/s41467-021-27385-3.
7. Chu H#, Duan Y#, Lang S, Jiang L, Wang Y, Llorente C, et al. (2020). The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease. Journal of Hepatology. 72(3):391-400. doi: 10.1016/j.jhep.2019.09.029. (2019 AASLD Early Career Investigator Award)
8. Gao B#, Duan Y#, Lang S, Barupal D, Wu TC, Valdiviez L, et al. (2020). Functional microbiomics reveals alterations of the gut microbiome and host co-metabolism in patients with alcoholic hepatitis. Hepatology Communications. 4(8):1168-1182. doi: 10.1002/hep4.1537. (Journal Cover)
9.Duan Y, Huey JD, Herman JK (2016). The DnaA inhibitor SirA acts in the same pathway as Soj (ParA) to facilitate oriC segregation during Bacillus subtilis sporulation. Molecular Microbiology. 102(3):530-544. doi: 10.1111/mmi.13477.
10. Duan Y#, Sperber AM#, Herman JK (2016). YodL and YisK possess shape-modifying activities that are suppressed by mutations in Bacillus subtilismreB and mbl. Journal of Bacteriology. 198(15):2074-2088. doi: 10.1128/JB.00183-16.
11. Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, et al.(2023). Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. Cell Host Microbe. 31(3):389-404. doi:10.1016/j.chom.2023.02.001.
12. Demir M#, Lang S#, Hartmann P#, Duan Y, Martin A, Miyamoto Y, Bondareva M, et al. (2022). The fecal mycobiome in non-alcoholic fatty liver disease. Journal of Hepatology. 76(4):788-799. doi: 10.1016/j.jhep.2021.11.029.
13. Hsu CL,Duan Y, Fouts DE, Schnabl B. (2021). Intestinal virome and therapeutic potential of bacteriophages in liver disease. Journal of Hepatology. 75(6):1465-1475. doi: 10.1016/j.jhep.2021.08.003.
14. Zhang Q, Ma C, Duan Y, Heinrich B, Rosato U, Diggs L, et al. (2021). Gut microbiome directs hepatocytes to recruit MDSC and promote cholangiocarcinoma. Cancer Discovery. 11(5):1248-1267. doi: 10.1158/2159-8290.CD-20-0304.
15. Jiang L#, Lang S#, Duan Y, Zhang X, Gao B, Chopyk J, et al. (2020). Intestinal virome in patients with alcoholic hepatitis. Hepatology. 72(6):2182-2196. doi: 10.1002/hep.31459.
16. Lang S, Duan Y, Liu J, Torralba MG, Kuelbs C, Ventura-Cots M, et al. (2020). Intestinal fungal dysbiosis and systemic immune response to fungi in patients with alcoholic hepatitis. Hepatology. 71(2):522-538. doi: 10.1002/hep.30832. (IF=17.425)
17. Lang S#, Demir M#, Martin A, Jiang L, Zhang X, Duan Y, Gao B, Wisplinghoff H, et al. (2020). Intestinal virome signature associated with severity of nonalcoholic fatty liver disease. Gastroenterology. 159(5):1839-1852. doi: 10.1053/j.gastro.2020.07.005.
18. Hendrikx T, Duan Y, Wang Y, Oh JH, Alexander LM, Huang W, et al. (2019). Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut. 68(8):1504-1515. doi: 10.1136/gutjnl-2018-317232.
19. Chu H, Duan Y, Yang L, and Schnabl B (2019). Small Metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease. Gut. 68(2):359-370. doi: 10.1136/gutjnl-2018-316307.
完整論(lun)文(wen)列表請(qing)見:Google Scholar: //scholar.google.com/citations?user=ACzdWz8AAAAJ&hl=en
招生招聘：
課(ke)題(ti)組(zu)誠聘具有微(wei)生物(wu)(wu)(wu)學(xue)、免疫(yi)學(xue)、細(xi)胞生物(wu)(wu)(wu)學(xue)、生物(wu)(wu)(wu)信(xin)息學(xue)、合成生物(wu)(wu)(wu)學(xue)等相關研究背景的(de)博(bo)士后及特(te)任副研究員，待(dai)遇從優(you)；同時(shi)熱忱歡迎(ying)對微(wei)生物(wu)(wu)(wu)與人體(ti)健(jian)康感(gan)興趣的(de)本科(ke)生加入課(ke)題(ti)組(zu)進行本科(ke)實習，及攻讀碩士、博(bo)士學(xue)位。
聯系方式：
Email:[email protected]