姓名：張凝 特任副研(yan)究員(yuan)

電(dian)話：0551-63602987

電子郵件：[email protected]

傳真：

主頁：

個人簡歷：

張凝，女，1982年(nian)生(sheng)(sheng)(sheng)。2004年(nian)在188bet足球獲得生(sheng)(sheng)(sheng)物(wu)學(xue)(xue)學(xue)(xue)士學(xue)(xue)位(wei)，2007年(nian)在188bet足球獲得細胞(bao)生(sheng)(sheng)(sheng)物(wu)學(xue)(xue)碩士學(xue)(xue)位(wei)，2012年(nian)在美(mei)國(guo)(guo)俄亥(hai)俄州(zhou)立(li)大學(xue)(xue)化學(xue)(xue)工程與生(sheng)(sheng)(sheng)物(wu)分(fen)子工程系獲得生(sheng)(sheng)(sheng)物(wu)化學(xue)(xue)博士學(xue)(xue)位(wei)。畢業后赴美(mei)國(guo)(guo)麻省理工學(xue)(xue)院(yuan)任助(zhu)研(yan)，隨后在美(mei)國(guo)(guo)哈佛大學(xue)(xue)醫學(xue)(xue)院(yuan)從事博士后研(yan)究。2014年(nian)初全職(zhi)回國(guo)(guo)，入職(zhi)188bet足球工作(zuo)。

主要研究方向：

1. 功能(neng)性有機小分子方向：

通過分(fen)析抗(kang)菌肽的(de)分(fen)子(zi)結構，設計、合成模擬抗(kang)菌肽功能的(de)小(xiao)(xiao)分(fen)子(zi)，并通過體外實驗(yan)和動(dong)物實驗(yan)來研究驗(yan)證其生物活(huo)性(xing)。這類(lei)新(xin)型(xing)抗(kang)菌小(xiao)(xiao)分(fen)子(zi)可(ke)望成為(wei)新(xin)一代廣譜抗(kang)菌藥物，并可(ke)向針對病毒、真(zhen)菌、原(yuan)蟲和癌細胞(bao)的(de)活(huo)性(xing)小(xiao)(xiao)分(fen)子(zi)方向擴展。

2. 功能性(xing)導電聚(ju)合物(wu)方(fang)向：

大量研究表明，電(dian)(dian)(dian)(dian)刺激對(dui)神(shen)(shen)(shen)經(jing)(jing)(jing)再生(sheng)(sheng)有明顯(xian)的(de)促進和(he)導向作用(yong)。我們已研制(zhi)(zhi)出一種具(ju)有高導電(dian)(dian)(dian)(dian)率和(he)生(sheng)(sheng)物(wu)相容性的(de)柔性導電(dian)(dian)(dian)(dian)聚(ju)合物(wu)材料(liao)，可用(yong)于神(shen)(shen)(shen)經(jing)(jing)(jing)信(xin)號(hao)采(cai)集和(he)刺激。在(zai)此基礎上(shang)，我們將(jiang)使用(yong)該材料(liao)制(zhi)(zhi)作可生(sheng)(sheng)物(wu)降解的(de)新型導電(dian)(dian)(dian)(dian)神(shen)(shen)(shen)經(jing)(jing)(jing)導管，并建立一套具(ju)有不同幾何構型的(de)導電(dian)(dian)(dian)(dian)神(shen)(shen)(shen)經(jing)(jing)(jing)導管模(mo)(mo)型，以(yi)實現(xian)電(dian)(dian)(dian)(dian)信(xin)號(hao)的(de)多種傳導模(mo)(mo)式，從而研究電(dian)(dian)(dian)(dian)信(xin)號(hao)傳導模(mo)(mo)式在(zai)神(shen)(shen)(shen)經(jing)(jing)(jing)再生(sheng)(sheng)中的(de)功能。這(zhe)將(jiang)對(dui)提高人造神(shen)(shen)(shen)經(jing)(jing)(jing)導管移植(zhi)手(shou)術的(de)效果，推動神(shen)(shen)(shen)經(jing)(jing)(jing)導管的(de)臨床應用(yong)起到積極作用(yong)。

文章及專著：

1.　L. Guo, M. Ma,N. Zhang, D. G. Anderson, and R. Langer, Organic Stretchable Multielectrode Array for Conformal Neural Interfacing, Adv. Mater., 2014. 26(9): p. 1427-1433.

2.　T.J. Styslinger, N. Zhang, V.S. Bhatt, N. Pettit, A.F. Palmer, and P.G. Wang. Site-Selective Glycosylation of Hemoglobin with Variable Molecular Weight Oligosaccharides: Potential Alternative to PEGylation. J. Am. Chem. Soc., 2012. 134 (17): p. 7507-7515.

3.　N. Zhang, and A.F. Palmer. Liposomes conjugated with human hemoglobin target delivery to macrophages. Biotechnol Bioeng, 2012. 109(3): p. 823-829.

4.   N. Zhang, and A.F. Palmer. Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic. Biotechnol Bioeng, 2011. 108(6): p. 1413-1420.

5.　N. Zhang, Y. Jia, G. Chen, P. Cabrales, and A.F. Palmer. Biophysical properties and oxygenation potential of high molecular weight polymerized human hemoglobins maintained in the tense and relaxed quaternary states. Tissue Eng Part A, 2011. 17(7-8): p. 927-940.

6.　N. Zhang, and A.F. Palmer. Polymerization of human hemoglobin using the cross-linker 1, 11-Bis(maleimido)triethylene glycol for use as an oxygen carrier. Biotechnol Prog, 2010. 26(5): p. 1481-1485.

7.　A.F. Palmer, N. Zhang, Y. Zhou, D.R. Harris and P. Cabrales. Small volume resuscitation from hemorrhagic shock utilizing high molecular weight tense-state polymerized hemoglobins. J Trauma, 2011. 71(4): p. 798-807.

8.　J. Elmer, P. Cabrales, Q. Wang, N. Zhang, and A.F. Palmer. Synthesis and biophysical properties of polymerized human serum albumins. Biotechnol Prog, 2011. 27(1): p. 290-296.

9.　N. Zhang, J. Liu, X. Ding, F. Aikhionbare, C. Jin, and X. Yao. FBXL5 interacts with p150Glued and regulates its ubiquitination. Biochem Biophys Res Commun, 2007. 359(1): p. 34-39.

10.  D. Liu,N. Zhang, J. Du, X. Cai, M. Zhu, C. Jin, Z. Dou, C. Feng, Y. Yang, L. Liu, K. Takeyasu, W. Xie, and X. Yao. Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis. Biochem Biophys Res Commun, 2006. 345(1): p. 394-402.