張海元，中國科(ke)學(xue)院長春應用化學(xue)研究所(suo)研究員、博士生導(dao)師。2005年畢業于中國科學(xue)(xue)院長春應用化(hua)學(xue)(xue)研究所并獲(huo)博士學(xue)(xue)位(wei)，2005至2013年期間(jian)先后在美國Wayne State University、Rensselaer Polytechnic Institute和University of California，Los Angeles從事科研工作。2014年至(zhi)今就職于中國科(ke)學院(yuan)長春應(ying)用化學研究所，2015年入選中(zhong)科院人才計(ji)劃(hua)。先后主持和參(can)與科技部重點(dian)研(yan)發計(ji)劃(hua)項(xiang)目(mu)、基金委國(guo)家自(zi)然(ran)科學(xue)基金項(xiang)目(mu)及吉(ji)林(lin)省科技廳醫藥重點研發項目。兼職《Materials》和《Nanoscience and Nanotechnology》等雜志編委、中(zhong)國(guo)毒(du)理(li)學會(hui)納米(mi)毒(du)理(li)學專業委員(yuan)會(hui)委員(yuan)、中(zhong)國生(sheng)物(wu)(wu)物(wu)(wu)理學(xue)(xue)會(hui)材料生(sheng)物(wu)(wu)學(xue)(xue)與(yu)智能診療技術(shu)分會(hui)委(wei)員會(hui)委(wei)員和國際納(na)米光(guang)電子學與生物光(guang)電子學聯合(he)中心學術委員會委員。
多(duo)年來(lai)致(zhi)力(li)于光電(dian)子活性納米(mi)體(ti)系的生物醫學應用研究，著重(zhong)于(yu)通過精(jing)確調控納米(mi)(mi)體(ti)(ti)系(xi)的能(neng)級電子(zi)結(jie)構，在(zai)納米(mi)(mi)生物(wu)(wu)界面水平考察納米(mi)(mi)體(ti)(ti)系(xi)與(yu)生物(wu)(wu)系(xi)統(tong)之間的電子(zi)傳遞和能(neng)量(liang)轉(zhuan)化，深(shen)入理解納米(mi)(mi)體(ti)(ti)系(xi)介導下(xia)的生物(wu)(wu)信號響應(ying)進(jin)程，促進(jin)多種生物(wu)(wu)醫學功能(neng)的完善與(yu)革新，實現了疾病的診斷與(yu)治療。研究成果先(xian)后發表(biao)于(yu)Advanced Materials、Angewandte Chemie International Edition、Journal of the American Chemical Society和Account Chemical Research等國際頂級學術期刊80余篇，授權發明(ming)專利8項，受邀參加國內外學術會(hui)議并做大(da)會(hui)報告(gao)和特邀報告(gao)20余次，研究成果被C&EN、AZoNano和Nanowerk等科(ke)技(ji)媒(mei)體(ti)醒目報道和重點推送(song)，指(zhi)導的研(yan)究生(sheng)先后兩(liang)次獲中金宝搏入口188光華(hua)獎學金。
研究領域：
納米生物醫用(yong)材(cai)料(liao)
智能藥(yao)物的(de)靶向遞(di)送與時空控釋
安全性納(na)米材料
代(dai)表性論(lun)著：
Yan, J.; Wang, Y.J.; Mu, Z.Z.; Han, X.Q.; Bi, L/P.; Wang, X.B.; Song, P.P.; Kang, Y.Q.; Wang, L.L; Zhang, X.Y.; Wang, Y.B.; Zhang, H. Y*. Gold Nanobipyramid-Mediated Apoptotic Camouflage of Adipocytes for Obesity Immunotherapy. Advanced Materials2022, 34, 2207686
Cheng, Y.; Kong, X. P.; Chang, Y.; Feng, Y. L.; Zheng, R. X.; Wu, X. Q.; Xu, K. Q.; Gao, X. F.; Zhang, H. Y., Spatiotemporally Synchronous Oxygen Self-Supply and Reactive Oxygen Species Production on Z-Scheme Heterostructures for Hypoxic Tumor Therapy. Advanced Materials2020, 32, 1908109.
Cheng, Y.; Chang, Y.; Feng, Y.; Jian, H.; Wu, X.; Zheng, R.; Xu, K.; Zhang, H. Y.*, Bismuth Sulfide Nanorods with Retractable Zinc Protoporphyrin Molecules for Suppressing Innate Antioxidant Defense System and Strengthening Phototherapeutic Effects. Advanced Materials2019, 31, 1806808.
Cheng, Y.; Chang, Y.; Feng, Y. L.; Jian, H.; Tang, Z. H.; Zhang, H. Y.*, Deep-Level Defect Enhanced Photothermal Performance of Bismuth Sulfide-Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging. Angewandte Chemie-International Edition2018, 57, 246-251.
Zhang, H. Y.; Pokhrel, S.; Ji, Z.; Meng, H.; Wang, X.; Lin, S.; Chang, C. H.; Li, L.; Li, R.; Sun, B.; Wang, M.; Liao, Y.-P.; Liu, R.; Xia, T.; Maedler, L.; Nel, A. E.*, Pdo Doping Tunes Band-Gap Energy Levels As Well As Oxidative Stress Responses To A Co3O4 P-Type Semiconductor In Cells And The Lung. Journal of the American Chemical Society 2014, 136, 6406-6420.
Zhang, H. Y.; Dunphy, D. R.; Jiang, X.; Meng, H.; Sun, B.; Tarn, D.; Xue, M.; Wang, X.; Lin, S.; Ji, Z.; Li, R.; Garcia, F. L.; Yang, J.; Kirk, M. L.; Xia, T.; Zink, J. I.; Nel, A.; Brinker, C. J.*, Processing Pathway Dependence Of Amorphous Silica Nanoparticle Toxicity: Colloidal Vs Pyrolytic. Journal of the American Chemical Society 2012, 134, 15790-15804.
Wang, L.; Chang, Y.; Feng, Y.; Li, X.; Cheng, Y.; Jian, H.; Ma, X.; Zheng, R.; Wu, X.; Xu, K.; Zhang, H. Y.*, Nitric Oxide Stimulated Programmable Drug Release of Nanosystem for Multidrug Resistance Cancer Therapy. Nano Letters2019, 19, 6800.
Liu, X.; Feng, Y.; Xu, G.; Chen, Y.; Luo, Y.; Song, J.; Bao, Y.; Yang, J.; Yu, C.; Li, Y.; Ye, H.; Ke, B.; Chen, B.; Hu, J.; Xu, J.; Meng, H.; Zhang, H. Y.*; Shi, H. *, MAPK-Targeted Drug Delivered by a pH-Sensitive MSNP Nanocarrier Synergizes with PD-1 Blockade in Melanoma without T-Cell Suppression. Advanced Functional Materials2019, 0, 1806916.
Chang, Y.; Feng, Y.; Cheng, Y.; Zheng, R.; Wu, X.; Jian, H.; Zhang, D.; Tang, Z.; Wang, Z.; Hao, J.; Zhang, H. Y.*, Anisotropic Plasmonic Metal Heterostructures as Theranostic Nanosystems for Near Infrared Light-Activated Fluorescence Amplification and Phototherapy. Advanced Science2019, 6, 1900158.
Liu, N.; Li, K.; Li, X.; Chang, Y.; Feng, Y. L.; Sun, X. J.; Cheng, Y.; Wu, Z. J.; Zhang, H. Y.*, Crystallographic Facet-Induced Toxicological Responses By Faceted Titanium Dioxide Nanocrystals. ACS Nano 2016, 10, 6062-6073.